The 2019 Toyota Tacoma V6 4x4 is less fuel efficient than 2WD models. The EPA rates the 2WD V6 at 21 MPG combined, while the 4WD V6 gets 20 MPG combined. This small gap of 1 MPG reflects the extra weight and mechanical drag of the 4x4 system.
Here is how fuel economy compares across key 2019 Tacoma V6 configurations:
| Drivetrain | Engine | Combined MPG | City MPG | Highway MPG |
|---|---|---|---|---|
| 2WD | 3.5L V6 Auto | 21 MPG | 19 MPG | 24 MPG |
| 4WD | 3.5L V6 Auto | 20 MPG | 18 MPG | 22 MPG |
| 4WD | 3.5L V6 Manual | 18 MPG | 17 MPG | 21 MPG |
According to the U.S. Department of Energy's 2025 fuel economy data, 4WD systems typically reduce fuel efficiency by 1 to 3 MPG compared to 2WD due to added drivetrain weight and friction (Source: fueleconomy.gov, 2025 Model Data). The 2019 Tacoma follows this pattern, with the automatic 4WD V6 losing just 1 MPG overall.
Real-world drivers report similar results. Based on data from 403 Fuelly vehicles covering over 11 million miles, the average 2019 Tacoma gets 18.09 MPG combined. However, V6 2WD models tend to cluster near 20: 21 MPG, while 4WD models average closer to 17: 19 MPG depending on driving style (Source: Fuelly, 2025 Owner Report).
If you want to maximize fuel savings, choose the 2WD V6 with an automatic transmission. You'll get the best city and highway numbers without sacrificing core performance. For heavy off-road use, 4WD is necessary, but it comes with a small fuel cost.
Sidekick can help you compare long-term ownership costs, including fuel, insurance, and maintenance for 2WD vs. 4WD Tacomas. Our data shows that over 5 years, the 2WD V6 saves about $180 in fuel alone at $3.50 per gallon.
Remember that driving habits matter more than drivetrain. Cruising at 65 mph on highways can boost your MPG by 2: 3 points regardless of 2WD or 4x4. Avoiding rapid acceleration and keeping tires properly inflated also helps maintain peak efficiency.