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FuelComparison2021 Honda Odyssey
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How does 2021 Honda Odyssey MPG compare to Toyota Sienna?

The 2021 Honda Odyssey gets 22 MPG combined. The Toyota Sienna gets 36 MPG combined. In 19301, switch to Sienna to save $927 per year on fuel. This assumes 15,000 miles driven yearly at $3.50 per gallon. The Sienna beats the Odyssey by 14 MPG.

View full 2021 Honda Odyssey cost analysis

2021 Honda Odyssey MPG vs Toyota Sienna

The 2021 Honda Odyssey gets 22 MPG combined. The Toyota Sienna gets 36 MPG combined. The Sienna wins on fuel economy. It beats the Odyssey by 14 MPG.

City, Highway, and Combined MPG

VehicleCity MPGHighway MPGCombined MPG
2021 Honda Odyssey192822
Toyota Sienna363636

Real-world tests match these EPA ratings. The Odyssey averages 22 MPG combined. The Sienna reaches 44 MPG on highways in some tests. Drivers report numbers close to these often.

Yearly Fuel Cost Savings in 19301

Gas costs $3.50 per gallon in 19301. You drive 15,000 miles per year.

VehicleGallons UsedYearly Cost
2021 Honda Odyssey682$2,387
Toyota Sienna417$1,460

Switch to the Sienna. You save $927 each year. Over 5 years, savings hit $4,635. Local gas prices set these figures.

Why the Difference?

The Odyssey runs a 3.5L V6 engine. It produces 280 horsepower. A 10-speed automatic transmission pairs with it. Power stays strong. Fuel use runs high.

The Sienna uses a 2.5L four-cylinder hybrid. Total power hits 245 horsepower. The hybrid setup cuts gas use. Some models offer AWD.

Tips to Maximize MPG in Your 2021 Odyssey

Boost your Odyssey's MPG with these steps:

  • Keep tires at 35 PSI. Check them monthly.
  • Use cruise control on highways.
  • Accelerate smoothly. Avoid hard starts.
  • Replace the air filter every 15,000 miles.
  • Track MPG with an app like Sidekick.

These changes add 1-2 MPG. You save more on gas. Plan routes ahead. Carry light loads. Clean wheels cut drag. Small habits add up fast.

How Sidekick Helps

Sidekick tracks your real MPG. It compares your Odyssey to the Sienna. View custom costs for 19301. Get alerts for low MPG.

Bottom line: Pick Sienna for top MPG and big savings. Choose Odyssey for power. Sidekick tracks it all to help you save.

People also ask

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More About the Honda Odyssey

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Last updated: February 11, 2026

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